The effects of Oldenlandia diffusa water extract on glucose metabolism and inflammation level in rats with streptozotocin-induced gestational diabetes mellitus

To reveal the effects of Oldenlandia diffusa (OD) on relieving progression and development gestational diabetes mellitus (GDM), explore underlying mechanism. A rat model GDM was established by streptozotocin injection. The OD rats were evaluated measuring levels fasting blood glucose (FBG), insulin, hemoglobin A1c (HbA1c), exposing to oral tolerance test (OGTT) histological evaluation pancreas. insulin inflammation response-related factors (tumor necrosis factor [TNF]-α, Interleukin [IL]-6 IL-1β) enzyme-linked immunosorbent assay (ELISA). Additionally, immunoblot performed investigate nuclear factor-κb (NF-κB) pathway 5' adenosine monophosphate-activated protein kinase (AMPK) pathway. decreased level, pancreatic tissue damage, secretion in rats. also reduced serum inflammatory (TNF-α, IL-6, Mechanically, could inhibit NF-κB activate AMPK affected metabolism level with streptozotocin-induced GDM, mechanism through might serve as a promising potential drug for treatment GDM.